Diagnosing Obstetric Cholestasis Pregnancy-specific reference ranges for liver function tests (LFTs) should be used. Other causes of itching and of liver dysfunction should be excluded. C - Postnatal resolution of pruritus and LFTs should be confirmed Treatment of Obstetric Cholestasis There is no evidence that any specific treatment improves maternal symptoms or neonatal outcomes. All such therapies should be discussed with the individual woman with this in mind. Topical Emollients C - Topical emollients are safe but their efficacy is unknown. S-Adenosyl Methionine A - There is insufficient evidence to show whether S adenosyl methionine is effective for either control of maternal symptoms or for improving fetal outcome. Ursodeoxycholic acid A - There are insufficient data to support the widespread use of ursodeoxycholic acid (UDCA) outside of clinical trials. Women should be aware of the lack of robust data concerning improvement in pruritus, protection again...