Diagnostic Workup Before Diagnosing Colic has been published by Carin E. Reust, MD, Center for Family Medicine Science, University of Missouri, Department of Family and Community Medicine, MA303 Health Sciences Center, Columbia, MO 65212 and Robert L. Blake, Jr, MD, Columbia, Arch Fam Med. 2000;9:282-283. The research relates to what diagnostic workup is appropriate before making the diagnosis of colic? The objectives of the research are as follows: A MEDLINE search (1966-present) was performed using the key word "colic," with limits to diagnosis, English language, and age group (newborn infants aged 0-1 month and infants aged 1-23 months). Seventeen articles were identified, of which 3 were specific for diagnosis. Two of these articles involved the diagnostic utility of acoustic analysis of crying, and 1 involved the use of a symptom diary. A similar strategy was used on MEDLINE (1996-present) to review infantile gastroesophageal reflux (GER).